Steady state: Cmin / PTF [NCA / SHAM]

posted by SDavis Homepage – UK, 2012-02-06 14:00  – Posting: # 8060
Views: 6,208

sorry for the late comment only just saw this;

» If you are able to estimate λz and tick [×] Intermediate Output in the Model Settings of NCA you get additionally the intercept (in log-scale) of the regression – which would allow to calculate an estimated Ĉmin value at t=τ. But this value is only given in the Core output (not available as a variable in the NCA Results)… :-(

The predicted Clast is extractable from the Summary table; here's a simple example with an Inner Join. See how sample time is JOINED AS Tlast, so obviously only truly appropriate where Tlast=Tau.

/********* Begin Mappings ********************/
Worksheet 1 : Project.Workflow.NCA.Final Parameters Pivoted
  Sort : Subject, Tlast
  Source Column :

Worksheet 2 : Project.Workflow.NCA.Summary Table
  Sort : Subject, Time [hr ]
  Source Column : Predicted [ng/mL]

Sort Map : (Internal)
/****************** End Mappings   ****************/

Simon
Senior Scientific Trainer
Pharsight - A Certara™ Company
Simon Davis at LinkedIn
https://www.certara.com/training/training-your-way
https://support.certara.com/forums/
Problems are not stop signs, they are guidelines. Robert H. Schuller

Complete thread:

Activity
 Admin contact
20,135 posts in 4,245 threads, 1,385 registered users;
online 3 (0 registered, 3 guests [including 3 identified bots]).
Forum time (Europe/Vienna): 02:58 CET

In the beginner’s mind there are many possibilities.
In the expert’s mind there are few.    Shunryu Suzuki

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5