Bioequivalence and Bioavailability Forum • Steady state: Cmin / PTF

Steady state: Cmin / PTF [NCA / SHAM]

posted by SDavis – UK, 2012-02-06 15:00 (4456 d 19:20 ago) – Posting: # 8060
Views: 10,323

sorry for the late comment only just saw this;

❝ If you are able to estimate λ_z and tick [×] Intermediate Output in the Model Settings of NCA you get additionally the intercept (in log-scale) of the regression – which would allow to calculate an estimated Ĉ_min value at t=τ. But this value is only given in the Core output (not available as a variable in the NCA Results)… :-(

The predicted Clast is extractable from the Summary table; here's a simple example with an Inner Join. See how sample time is JOINED AS Tlast, so obviously only truly appropriate where Tlast=Tau.

/********* Begin Mappings ********************/

Worksheet 1 : Project.Workflow.NCA.Final Parameters Pivoted

  Sort : Subject, Tlast

  Source Column : 



Worksheet 2 : Project.Workflow.NCA.Summary Table

  Sort : Subject, Time [hr ]

  Source Column : Predicted [ng/mL]



Sort Map : (Internal)

/****************** End Mappings   ****************/

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Complete thread:

Steady state: Cmin / PTF Helmut 2011-03-08 15:30
- Steady state: Cmin / PTFSDavis 2012-02-06 14:00
  - Steady state: Cmin / PTF Helmut 2012-02-06 14:24
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      - Originators | generics (Cmin | Cτ) Helmut 2019-02-04 13:18
        
        Down with Big Brother Astea 2019-02-04 13:51
        
        Down with Big Brother Helmut 2019-02-04 14:43
        
        thoughtcrime Astea 2019-02-04 15:13
        
        blackwhite Helmut 2019-02-04 15:34
        
        animal farm Astea 2019-02-04 15:53