Bioequivalence and Bioavailability Forum

Dear EM, dear Helmut,

First thanx for your thoughts.

@ EM:

❝ ❝ -What is the geometric mean in replicate cross-over studies? Overall or calculated for each replicate?

❝ They mean lsmeans or model effects, I hope ...

Do you really won't me to do a model fit (which if we are allowed to only consider Reference AUC values?) for the log-transformed values, leaving out each subjects values in turn, and then apply the 5% criterion via exponentiated LSmeans?
My first thought was simpler: Calculate the geometric means leaving out each subjects values in turn and then calculate the percentage of the individual value versus geometric mean (i.e. taken the guidance text literally).

❝ Pick the one that fits.

How do you define "fit"?

❝ "Geometric mean" is a term that should be banned ...

Totally
What the hell do you have against geometric means? Enlighten me.