Bioequivalence and Bioavailability Forum • CV from CI: manual, PowerTOST, FARTSIE.xls

CV from CI: manual, PowerTOST, FARTSIE.xls [Power / Sample Size]

posted by Helmut – Vienna, Austria, 2012-01-16 15:27 (5260 d 12:29 ago) – Posting: # 7949
Views: 8,036

Dear Karthik!

Strange. In the following all intermediate steps (rounded values from the presentation and full internal precision; CL_lo 0.91, CL_hi 1.15, n₁ 11, n₂ 10):

            rounded   full prec.

PE           1.023     1.022986

∆CL          0.11702   0.117036

(numerator)

t            1.729     1.729131

denominator  0.755450  0.755512

num/denom    0.154911  0.154910

squared      0.023990  0.023997

MSE          0.047980  0.047994

(squared ×2!)
CV 22.2% 22.1731%

Quite close to R package PowerTOST:

require(PowerTOST)

100*CVfromCI(lower=0.91, upper=1.15, n=21, design = "2x2", alpha = 0.05)

[1] 22.19886

FARTSSIE.xls (Bioequivalence, Crossover) ISV from Published Point Estimate and CI:
NA, 0.91, 1.15, 90, 21 ⇒ ISV = 22.2%

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz

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Complete thread:

manual power calculation Karthik 2011-03-17 10:17 [Power / Sample Size]
- manual power calculation: why? Helmut 2011-03-28 14:40
  - manual power calculation: why? K2K 2012-01-16 12:56
    - FARTSSIE.xls Helmut 2012-01-16 13:14
      - FARTSSIE.xls K2K 2012-01-16 13:21
        
        CV from CI: manual, PowerTOST, FARTSIE.xlsHelmut 2012-01-16 14:27
        
        CV from CI: manual, PowerTOST, FARTSIE.xls K2K 2012-01-18 09:35