Bioequivalence and Bioavailability Forum

Dear sir

we want to calculate intersubject CV from reference literature in that they given mean, CI we calculated intra CV from CI? then how to calculate Inter CV?
how to calculate inter subject CV from arithmetic mean or Standard devation? its possible to calculate?
or we can able to calculate inter subject CV from intrasubject cv?
pls guide ME thanks in advance

Dear Karthik,
questions in the BEBA-Forum only, please! Some hints:

• CV_intra from a cross-over’s CI ⇒ possible
  
• CV_inter from mean ± SD ⇒ not possible (only ≈ CV_total)
  
• CV_inter from CV_intra ⇒ not possible

BTW, why do want to get CV_inter? For a cross-over you need CV_intra and for a parallel design CV_total.
Best regards, Helmut

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Dear Sir

Good morning

❝ why do want to get CVinter?

according to WHO BTIF(bioequivalence trial information form) in that section 7.4.
WHO are asking to compare our study report with reference literature report in that they are asking to calculate intersubject cv how its possible to calculate with mean and standard deviation so please guide me.

thanks and regards
karthik

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Edit: First section of the post was copypasted from the guestbook. BTIF linked. [Helmut]