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Registervolume of distribution at steady state [PK / PD]
Dear all!
I have a questions regarding calculation of volume of distribution at steady state (Vss). After IV bolus administration Vss can be calculated based on the non-compartmental theory as doseiv x AUMC0-infinity / AUC20-infinity. Now let us assume that the concentrations over time after extra vascular administration can be adequately described by a one-compartmental model with first order absorption and first order elimination.
How can the volume of distribution at steady state be calculated under this model? Can the above formula be adjusted straightforwardly using the bioavailability F to calculate Vss = (dosepo x F x AUMC0-infinity) / AUC20-infinity?
best regards
Martin
I have a questions regarding calculation of volume of distribution at steady state (Vss). After IV bolus administration Vss can be calculated based on the non-compartmental theory as doseiv x AUMC0-infinity / AUC20-infinity. Now let us assume that the concentrations over time after extra vascular administration can be adequately described by a one-compartmental model with first order absorption and first order elimination.
How can the volume of distribution at steady state be calculated under this model? Can the above formula be adjusted straightforwardly using the bioavailability F to calculate Vss = (dosepo x F x AUMC0-infinity) / AUC20-infinity?
best regards
Martin
Complete thread:
- volume of distribution at steady statemartin 2011-10-18 07:49
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Vss d_labes 2011-10-18 11:36
- History Helmut 2011-10-18 16:02
- History javier 2016-09-21 16:47
- Amazon? Yes. yjlee168 2016-09-22 11:30
- Gold Letters d_labes 2016-09-22 12:09
- Gold Letters yjlee168 2016-09-24 20:26
- Another quest mittyri 2016-09-25 15:04
- TopFit: 16bit DOS-application Helmut 2016-09-25 23:41
- TopFit: less than 1.44 MB mittyri 2016-09-26 00:02
- TopFit: less than 1.44 MB Helmut 2016-09-26 00:17
- TopFit: less than 1.44 MB ElMaestro 2016-09-26 09:43
- TopFit: less than 1.44 MB Helmut 2016-09-26 00:17
- TopFit: 16bit DOS-application yjlee168 2016-09-26 00:18
- TopFit: less than 1.44 MB mittyri 2016-09-26 00:02
- TopFit: 16bit DOS-application Helmut 2016-09-25 23:41
- Another quest mittyri 2016-09-25 15:04
- Gold Letters yjlee168 2016-09-24 20:26
- Gold Letters d_labes 2016-09-22 12:09
- Amazon? Yes. yjlee168 2016-09-22 11:30
- History javier 2016-09-21 16:47
- History Helmut 2011-10-18 16:02
- volume of distribution at steady state ElMaestro 2016-09-23 23:13
- Vss: MIT is needed anyway... mittyri 2016-09-24 00:38
- it seems possible for me... yjlee168 2016-09-24 20:19
- Leslie disagrees mittyri 2016-09-24 21:33
- OK! we cannot calculate Vdss with dataset from extravascular dosing alone yjlee168 2016-09-25 23:27
- MRTINF includes Mean Input Time mittyri 2016-09-25 23:45
- “Gravity Duration” Helmut 2016-09-25 23:47
- OK! we cannot calculate Vdss with dataset from extravascular dosing alone yjlee168 2016-09-25 23:27
- Leslie disagrees mittyri 2016-09-24 21:33
- Was Leslie wrong about Eq (8)? yjlee168 2016-09-26 00:13
- Leslie cannot be wrong mittyri 2016-09-26 00:23
- it seems possible for me... yjlee168 2016-09-24 20:19
- Vss: MIT is needed anyway... mittyri 2016-09-24 00:38
- Vss d_labes 2011-10-18 11:36
Ing. Helmut Schütz