Bioequivalence and Bioavailability Forum

Hi,

I have a 3 period, 2 treatment crossover (TRR, RTT) design and I've been asked to construct CI's for Tmax. Since the data is not normal, I plan to construct Hodges Lehmann CI's.

From reading Shein-Chung Chow, Jen-pei Liu. Design and Analysis of Bioavailability and Bioequivalence Studies Third Edition, it would appear I should calculate the pairwise calculations using the following formula:

Dik=1/4(2Yi1k - Yi2k - Yi3k) where i= number of differences & k= number of sequences.

Usually, Dik=Yi1 - Yi2

However, from looking at the SAS online help section, I cannot see a way of stipulating this using PROC NPAR1WAY. Do you have any suggestions?

Thanks!

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Edit: Category changed. [Helmut]