Bioequivalence and Bioavailability Forum

Main page Policy/Terms of Use Abbreviations Latest Posts

 Log-in |  Register |  Search

Back to the forum  Query: 2018-01-16 10:34 CET (UTC+1h)
 

Questions and Ambiguities [BE/BA News]

posted by d_labes - Berlin, Germany, 2011-03-28 14:16  - Posting: # 6822
Views: 13,916

Dear Helmut,

» Period ratios (second / first administration):
» Type 3: SAS according to R-doc - 2 outliers (#46: 3.524, #45: 26.08)
» Type 5: or is this SAS? - 2 outliers
» Type 6: Minitab, SPSS, Phoenix/WinNonlin - 2 outliers
» ...

SAS has 5 different percentile definitions. The default is:
Let n*p=j+g where j is the integer part, g is the fractional part, n is the number of values, x the ordered values.
Let y denote the percentile. Then (SAS PCTLDEF=5)
  y = 0.5*(xj+xj+1) if g=0
  y = xj           if g>0

This corresponds to R's Type 2 I think.

» Don’t know what to do. :confused: Suggestions?

If the 'outlier' considerations based on the crippled EMA model makes any sense at all, which I'm not convinced at all :no:, I would vote for an analysis of the residuals, not the period ratios also they appeared a natural choice on the first view.
Pro's:Con's:But these Con's are unavoidable because of the EMA 'model', whatever here is modelled.
To add more ambiguities:

Regards,

Detlew

Complete thread:

Back to the forum Activity
 Mix view
Bioequivalence and Bioavailability Forum | Admin contact
17,667 Posts in 3,778 Threads, 1,101 registered users;
27 users online (0 registered, 27 guests).

In matters of style, swim with the current;
in matters of principle, stand like a rock.    Thomas Jefferson

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
XHTML/CSS RSS Feed