Bioequivalence and Bioavailability Forum

Subtleties, flaws, questions [BE/BA News]

posted by Helmut  – Vienna, Austria, 2011-03-27 20:35  – Posting: # 6818
Views: 25,937

Dear D. Labes!

» Source         DF   Type III SS   Mean Square  [...]
»
» sequence        0    0.0000000    .            [...]
» [...]

Zero degrees of freedom is not a lot.
I love SAS‘s ‘.’ - Phoenix/WinNonlin spits out ‘Not estimable’, but I can trim it to ‘.’ or even ‘0’…

Open issues IMHO:

• Outliers – which method? Model residuals or R/R ratios?
  
• Obviously EMA is not interested in CV_WT (Method C) at all. Since GLM throws away incomplete data (Method A), why should one go with a full replicate design? More periods, more chances of drop-outs.

—
Cheers,
Helmut Schütz


The quality of responses received is directly proportional to the quality of the question asked. ☼
Science Quotes

Complete thread:

• EMA BE-GL: Clarifications / Corrections? Helmut 2010-06-22 18:53 [BE/BA News] 
  • Good news!? d_labes 2010-06-23 10:09
    • Good news!? Helmut 2010-06-23 10:11
      • Update Helmut 2011-02-05 18:48
        • Q&A published 14 March 2011 Helmut 2011-03-16 13:44
          • Q&A published 14 March 2011 ElMaestro 2011-03-16 14:20
          • Phoenix/WinNonlin 6.1.0.173 Helmut 2011-03-17 04:23
          • ANOVA party prevails d_labes 2011-03-17 11:00
            • THX! Helmut 2011-03-19 02:59
              • Outlier d_labes 2011-03-24 11:55
                • Outliers - yes, but how? Helmut 2011-03-24 15:09
                  • Questions and Ambiguities d_labes 2011-03-28 14:16
                  • Residuals and Outliers in Replicate Design Crossover Studies d_labes 2011-04-04 08:53
              • Info requested ElMag 2011-03-24 12:45
                • Confused as well... Helmut 2011-03-24 16:50
          • Q&A published 14 March 2011 Priyanka_S 2011-03-21 14:28
            • SAS code: Warning d_labes 2011-03-21 16:08
              • Copy & paste Helmut 2011-03-21 22:38
                • Subtleties, flaws, questions d_labes 2011-03-22 09:24
                  • Subtleties, flaws, questions Helmut 2011-03-27 20:35
                    • Not estimable in the model The user 2017-03-14 10:16
                      • Not estimable in the model ElMaestro 2017-03-14 11:02
                        • Not estimable in the model The user 2017-03-14 12:13
                          • Not estimable in the model ElMaestro 2017-03-14 12:41
                      • Not estimable in the model Helmut 2017-03-18 21:59