Bioequivalence and Bioavailability Forum 12:34 CET

Subtleties, flaws, questions [BE/BA News]

posted by Helmut - Vienna, Austria, 2011-03-27 20:35  - Posting: # 6818
Views: 21,931

Dear D. Labes!

» Source         DF   Type III SS   Mean Square  [...]
»
» sequence        0    0.0000000    .            [...]
» [...]

Zero degrees of freedom is not a lot.
I love SAS‘s ‘.’ - Phoenix/WinNonlin spits out ‘Not estimable’, but I can trim it to ‘.’ or even ‘0’…

Open issues IMHO:

• Outliers – which method? Model residuals or R/R ratios?
  
• Obviously EMA is not interested in CV_WT (Method C) at all. Since GLM throws away incomplete data (Method A), why should one go with a full replicate design? More periods, more chances of drop-outs.

—
Cheers,
Helmut Schütz


The quality of responses received is directly proportional to the quality of the question asked. ☼
Science Quotes

Complete thread:

• EMA BE-GL: Clarifications / Corrections? - Helmut, 2010-06-22 18:53 [BE/BA News] 
  • Good news!? - d_labes, 2010-06-23 10:09
    • Good news!? - Helmut, 2010-06-23 10:11
      • Update - Helmut, 2011-02-05 18:48
        • Q&A published 14 March 2011 - Helmut, 2011-03-16 13:44
          • Q&A published 14 March 2011 - ElMaestro, 2011-03-16 14:20
          • Phoenix/WinNonlin 6.1.0.173 - Helmut, 2011-03-17 04:23
          • ANOVA party prevails - d_labes, 2011-03-17 11:00
            • THX! - Helmut, 2011-03-19 02:59
              • Outlier - d_labes, 2011-03-24 11:55
                • Outliers - yes, but how? - Helmut, 2011-03-24 15:09
                  • Questions and Ambiguities - d_labes, 2011-03-28 14:16
                  • Residuals and Outliers in Replicate Design Crossover Studies - d_labes, 2011-04-04 08:53
              • Info requested - ElMag, 2011-03-24 12:45
                • Confused as well... - Helmut, 2011-03-24 16:50
          • Q&A published 14 March 2011 - Priyanka_S, 2011-03-21 14:28
            • SAS code: Warning - d_labes, 2011-03-21 16:08
              • Copy & paste - Helmut, 2011-03-21 22:38
                • Subtleties, flaws, questions - d_labes, 2011-03-22 09:24
                  • Subtleties, flaws, questions - Helmut, 2011-03-27 20:35
                    • Not estimable in the model - The user, 2017-03-14 10:16
                      • Not estimable in the model - ElMaestro, 2017-03-14 11:02
                        • Not estimable in the model - The user, 2017-03-14 12:13
                          • Not estimable in the model - ElMaestro, 2017-03-14 12:41
                      • Not estimable in the model - Helmut, 2017-03-18 21:59