## Phoenix/WinNonlin 6.1.0.173 [BE/BA News]

Dear all,

I could reproduce EMA’s results in Phoenix. Interesting points for Dataset II:
• Method C (FDA’s 2001 Appendix E)
Warning: Newton's algorithm converged with modified Hessian. Output is suspect. Model may be over-specified. A simpler model could be tried.
• A result for CVWT of 8.65%… T is not replicated – we had that already; too lazy to search now.

Cheers,
Helmut Schütz

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