Paired Design in WinNonlin [Software]

posted by Helmut Homepage – Vienna, Austria, 2007-04-06 00:23  – Posting: # 639
Views: 11,896

» I'm waiting for a correct implementation of a paired design (e.g., comparing steady state AUC with single dose AUC in the same subjects) since February 25th, 2007... :angry:

Does Pharsight monitor this site?

Just received the model specification from their support after 40 days of useless e-mails (RTFM); in case somebody needs it (a paired design is neither given in the manual, nor the support site):

Bioequivalence Wizard > Type of Study > Parallel/Other
Choose Treatment and Reference value > Next
Drag 'subject' from the 'Variable Collection' to 'Classification Variables'
Model Specification:
subject+treatment > Next and proceed as usual

WinNonlin's results are identical with NCSS 2001 and EquivTest/PK.

Cheers,
Helmut Schütz
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