Bioequivalence and Bioavailability Forum • Paired Design in WinNonlin

Paired Design in WinNonlin [Software]

posted by Helmut – Vienna, Austria, 2007-04-06 02:23 (7018 d 02:55 ago) – Posting: # 639
Views: 22,156

❝ I'm waiting for a correct implementation of a paired design (e.g., comparing steady state AUC with single dose AUC in the same subjects) since February 25^th, 2007... :angry:

Does Pharsight monitor this site?

Just received the model specification from their support after 40 days of useless e-mails (RTFM); in case somebody needs it (a paired design is neither given in the manual, nor the support site):

Bioequivalence Wizard > Type of Study > Parallel/Other
Choose Treatment and Reference value > Next
Drag 'subject' from the 'Variable Collection' to 'Classification Variables'
Model Specification:
subject+treatment > Next and proceed as usual

WinNonlin's results are identical with NCSS 2001 and EquivTest/PK.

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Complete thread:

assessment of steady state in WinNonLin pkpdpkpd 2007-04-04 22:52 [Software]
- steady state in WinNonlin (example) Helmut 2007-04-05 02:30
  - steady state in WinNonlin (example) pkpdpkpd 2007-04-05 16:33
    - steady state in WinNonlin (example) Helmut 2007-04-05 17:16
      - steady state in WinNonlin (example) pkpdpkpd 2007-04-05 17:39
        
        steady state in WinNonlin… Helmut 2007-04-05 18:40
        
        steady state in WinNonlin… pkpdpkpd 2007-04-05 21:37
        Paired Design in WinNonlinHelmut 2007-04-06 00:23
  - steady state in WinNonlin (example) apapanas 2018-01-03 14:44
    - steady state in WinNonlin (example) Helmut 2018-01-04 17:11
      - qt in WinNonlin mittyri 2018-01-04 23:13
        
        ‘Deep’ bug Helmut 2018-01-05 00:37
        Workarounds for v6.3+ Helmut 2018-01-08 00:40
        
        Workarounds for v6.3+ apapanas 2018-01-10 12:47