time-dependent clearance [Tips / Tricks]

posted by luvblooms4u – 2010-11-12 06:29 (4885 d 05:50 ago) – Posting: # 6139
Views: 17,141

Dear yjlee168:,

❝ I guess you're talking about time-dependent clearance here.


Yes and No,
I am a bit confused though. Actually I was trying to see the cell proliferation dependent clearance.

❝ Yes and no. It depends on the changes of clearance (Cl). However, you may need to know when Cl is going to change (its starting time and stopping time) first. Of course, you can have as many as Cls you want, only if you need to know each Cl's starting time and stopping time to switch to different Cl. That's the difficult part. However, you figure it out from your data by plotting all data with 'Conc. vs. Time' first; and make your guess. It may take you some time to get good guess (trial-and-error).


Actually I am mainly looking for the Tissue metabolism related effects which may not be observed in 'Conc. vs. Time' graph.I think I am thinking in a right way!!

❝ ❝ 2. Is there any PK PD model is available for the same?

❝ Not totally the same but should have a lot of similar PK/PD models. You can look for Pubmed with keyword "time-dependent clearance" or google it.


Thanks a lot. I will look for the same.

❝ I think you may need to create this model yourself to fit your data (needs).


Thanks a lot for your suggestion.

Let me search and try them then I will be back!

Luvbloms :ok:

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