Bioequivalence and Bioavailability Forum

Actual time of sampling should be used in the estimation of the pharmacokinetic parameters. In studies to determine bioequivalence after a single dose, AUC(0-t), AUC(0-∞), residual area, Cmax and tmax should be determined. In studies with a sampling period of 72 h, and where the concentration at 72 h is quantifiable, AUC(0-∞) and residual area do not need to be reported; it is sufficient to report AUC truncated at 72h, AUC(0-72h).

---

Edit: Full quote removed. Please delete anything from the text of the original poster which is not necessary in understanding your answer; see this post! [Helmut]