Bioequivalence and Bioavailability Forum

Timing of high-fat breakfast [Design Issues]

posted by Dr Andrew Leary – Ireland, 2010-08-24 14:13 (5768 d 07:36 ago) – Posting: # 5823
Views: 7,557

Hello Helmut and co.

I trust that heatwave and floods are over and that you're having good weather for the last part of summer. The sun is shining here in Ireland!

Does anyone have a view on the timing of the high fat breakfast? In the past we've used (a) breakfast to start 30min before dosing (to be completed prior to dosing), and (b) breakfast to start immediately after dosing. I guess it is also possible to dose subjects when they're halfway through breakfast.

Is there any evidence (or guidance) to support one approach over another? Is one approach likely to increase variability compared to another?

All opinions / comments gratefully received!

Kind regards

Complete thread:

• Timing of high-fat breakfastDr Andrew Leary 2010-08-24 12:13 [Design Issues] 
  • It's breakfast time d_labes 2010-08-24 13:00
    • Yummz ElMaestro 2010-08-24 15:09
      • Yummz Dr Andrew Leary 2010-08-24 16:22
      • Reading matters Helmut 2010-08-24 16:34
    • It's breakfast time Dr Andrew Leary 2010-08-24 16:20
      • It's breakfast time Pavidus 2010-08-25 14:11
        • It's breakfast time Dr Andrew Leary 2010-08-25 14:52
          • It's breakfast time ElMaestro 2010-08-25 15:14
          • It's breakfast time Ohlbe 2010-08-25 16:07
            • It's breakfast time Dr Andrew Leary 2010-08-25 16:15
        • It's breakfast time Dr_Dan 2010-08-25 15:33
          • It's breakfast time Dr_Dan 2010-08-25 15:49
            • It's breakfast time Helmut 2010-08-25 16:22
              • It's breakfast time Pavidus 2010-08-26 10:02