Log in
RegisterNon Linearity (SD vs. MD) [PK / PD]
posted by Helmut 
– Vienna, Austria, 2010-08-13 21:11 (5778 d 23:34 ago) – Posting: # 5785
Views: 7,249
Dear ElMestro & Cmax (interesting nick)!
... and the design depends on how much previous information about the drug one has. Single dose studies generally suffice for most drugs, but for new drugs (i.e., full characterisation of pharmacokinetics) one has to opt for steady state. Otherwise time-dependent effects (e.g., enzyme-induction or -inhibition) may not be detected.
❝ To investigate linearity several dose levels need to be investigated.
... and the design depends on how much previous information about the drug one has. Single dose studies generally suffice for most drugs, but for new drugs (i.e., full characterisation of pharmacokinetics) one has to opt for steady state. Otherwise time-dependent effects (e.g., enzyme-induction or -inhibition) may not be detected.
—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Non Linearity Cmax 2010-08-13 18:12 [PK / PD]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Non Linearity ElMaestro 2010-08-13 18:31
- Non Linearity (SD vs. MD)Helmut 2010-08-13 19:11
- Non Linearity (SD vs. MD) Cmax 2010-08-27 20:04
- BE # dose proportionality Helmut 2010-08-28 14:29
- Non Linearity (SD vs. MD) Cmax 2010-08-27 20:04
- Non Linearity (SD vs. MD)Helmut 2010-08-13 19:11
- Non Linearity ElMaestro 2010-08-13 18:31
Ing. Helmut Schütz