Donepezil SR 23 mg Tablets BE study [Study Per­for­mance]

posted by madhavaraob – 2010-07-22 11:06 (5467 d 06:18 ago) – Posting: # 5661
Views: 11,487

Dear Members,

Thank You very much Dr.Gunasakaran for your reply. I still had a doubt regarding the use of antiemetic for Donepezil as it was clearly reported that it causes severe nausea and vomiting. I would like you suggest a proper Antiemetic in order to avoid emesis and subject withdrawal in the conduct of Bioequivalence study.
Is it approriate to choose Ondansetron (a substrate of CYP 3A4) as an antiemetic in BA/BE study of Donepezil (which is also a substrate of CYP 3A4) in order to avoid emesis? It would be highly appreciated if u share any literature study conducted on donepezil using antiemetic.

Thanking You in ancipation
Awaiting Your Reply.

Regards,
MadhavRaoB

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