Bioequivalence and Bioavailability Forum

CI for Transformed data Unbalanced study [General Sta­tis­tics]

posted by usfda_emea – 2007-03-07 07:21 (6257 d 19:11 ago) – Posting: # 564
Views: 28,812

Dear HS,

❝ I guess that’s not your real name

❝ Let’s call Xt the LSM of the test, and Xr the LSM of the reference (log-scale).

Can you help me with the formula for LSM (I wish to do a manual calculation, for verification purposes) and a brief explaination about why this method is used for unbalanced study?

Thanks a million for the other formula and the references.

Truly,
USFDA_EMEA

Complete thread:

• Confidence Interval for Transformed data Unbalanced study usfda_emea 2007-03-06 14:39 
  • CI for Transformed data Unbalanced study Helmut 2007-03-06 16:46
    • CI for Transformed data Unbalanced study drshiv 2007-03-06 18:49
    • CI for Transformed data Unbalanced studyusfda_emea 2007-03-07 06:21
      • CI for Transformed data Unbalanced study Helmut 2007-03-07 12:04
        • CI for Transformed data Unbalanced study usfda_emea 2007-03-07 12:34
        • CI for Transformed data Unbalanced study Ohlbe 2014-07-30 15:04
          • LSM limbo Helmut 2014-07-31 02:54
            • LSM limbo Ohlbe 2014-07-31 09:47
            • 90% CI limbo VStus 2017-03-01 14:07
              • RSABE ⇒ ABEL Helmut 2017-03-03 13:34
                • RSABE ⇒ ABEL VStus 2017-03-03 15:31
                  • s2wR != mse, FDA != EMA d_labes 2017-03-04 14:49
                    • s2wR != mse, FDA != EMA ElMaestro 2017-03-04 19:13
                      • s2wR from ISC in FDA approach d_labes 2017-03-05 12:18
                        • s2wR from ISC in FDA approach ElMaestro 2017-03-05 13:50
                    • s2wR != mse, FDA != EMA VStus 2017-03-04 21:41
                      • s2wR != mse, FDA != EMA Helmut 2017-03-06 13:40