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Confidence Interval for Transformed data Unbalanced study [General Sta­tis­tics]

posted by usfda_emea - 2007-03-06 14:39  - Posting: # 559
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I am looking for help on estimation of 90% confidence interval for log transformed data of AUC (0-inf) for a bioequivalence study. This study involved two-way crossover, two-period, two-sequence design with a total of 33 subjects completing the study. Each sequence had Period I TR=16 and RT=17, and in Period II TR=17 and RT=16; thus, total of 33 completed the study.

In order to estimate the 90% confidence interval, can some one help me with the formula and a worked out example for the ease of understanding. OR Guide me to a site where this can be found.

I believe least-squares mean estimate for each formulation needs to be used to form the difference, together with the standard error. However, in lack of exact formula i am seeking the help of experts out there.

Thanks in advance for the help.

Edit: Category changed. [Helmut]

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