Bioequivalence and Bioavailability Forum • F value for sequence effect

#5273F value for sequence effect (R for BE/BA)

posted by Pakawadee, 2010-05-03 11:48

Response: lnCmax

          Df   Sum Sq  Mean Sq F value Pr(>F)

seq        1 0.000017 0.000017  0.0011 0.9743

prd        1 0.027294 0.027294  1.7187 0.2144

drug       1 0.025583 0.025583  1.6110 0.2284

seq:subj  12 0.255270 0.021273  1.3395 0.3103

Residuals 12 0.190565 0.015880

The above ANOVA table is an example in this webpage. I am confused about F value of sequence. Why it is 0.0011 (=MSseq/MSresidual)? I think it should be 0.0008 (=MSseq/MSsubj). Due to my knowledge in statistic is very limit, I afraid that I would missunderstand some concept of ANOVA for BE. May anyone help to explain?
Thanks
Pakawadee

Edit: Not in this webpage, but in the example (second output) of bear's homepage. BTW, testing for a sequence effect (or unequal carry-over, if you like) in 2×2 cross-over studies is futile anyhow (see this post). [Helmut]

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Complete thread:

F value for sequence effect - Pakawadee, 2010-05-03 11:48 (R for BE/BA)
- F value for sequence effect - AA, 2010-05-03 13:38
- F value for sequence effect - Ohlbe, 2010-05-03 14:16
  - F value for sequence effect - Pakawadee, 2010-05-04 03:48
    - F value for sequence effect - ElMaestro, 2010-05-04 08:48
      - F value for sequence effect - Pakawadee, 2010-05-04 12:12
      - F value; rounding - HS, 2010-05-04 13:00
        log rounding machine - d_labes, 2010-05-04 13:35
        Rounding or not to rounding - yjlee168, 2010-05-04 21:27
        Rounding or not to rounding - ElMaestro, 2010-05-04 23:23
        Rounding or not to rounding - yjlee168, 2010-05-05 01:17
        Rounding or not to rounding - ElMaestro, 2010-05-05 12:15
        Rounding or not to rounding - yjlee168, 2010-05-05 12:59
        Rounding or not to rounding - ElMaestro, 2010-05-05 13:15
        Rounding or not to rounding - yjlee168, 2010-05-05 13:28
        Type III SS sequence effect -revised - yjlee168, 2010-05-05 23:58
        Type III SS sequence effect -revised - ElMaestro, 2010-05-06 07:27
        SAS-like Type III SS sequence with bear? - yjlee168, 2010-06-03 13:04
        New dataset? - d_labes, 2010-05-05 11:40
        New dataset? - yjlee168, 2010-05-05 12:31
        log to 3 decimals guess work - d_labes, 2010-05-05 16:00
        log to 3 decimals guess work - yjlee168, 2010-05-05 20:13
        rounding and presentation of data - HS, 2010-05-05 20:29
        rounding and presentation of data - yjlee168, 2010-05-05 21:05
        rounding and presentation of data in R - martin, 2010-05-06 07:53
        Canadian logs - d_labes, 2010-05-06 10:12
        Canadian logs - ElMaestro, 2010-05-06 10:21
        Canadian logs - HS, 2010-05-06 14:57
        Canadian lost - d_labes, 2010-05-06 15:38