WNL in replicate BE [🇷 for BE/BA]

posted by yjlee168 Homepage – Kaohsiung, Taiwan, 2010-04-26 10:59 (5085 d 07:50 ago) – Posting: # 5228
Views: 55,611

Dear Helmut,

One of bear users found the differences when he compared bear and WNL with his dataset obtained from a replicate BE study. I found that the mixed effect model used in WNL v6.x was different from bear. In WNL, the fixed terms included: int + SEQUENCE + FORMULATION + PERIOD; and the random terms: FORMULATION*SUBJECT + PERIOD*FORMULATION*SUBJECT. I don't know why WNL sets its models like this. In bear, the fixed effects were SEQUENCE + PERIOD + FORMULATION; the random effect was only FORMULATION/SUBJECT. That's why I asked the question. I should search first, like this post of yours... :-(

❝ What do you mean by "acceptable"?


All the best,
-- Yung-jin Lee
bear v2.9.1:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here

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