Bioequivalence and Bioavailability Forum • package PK

package PK [🇷 for BE/BA]

posted by Jack – Lancaster, United Kingdom, 2010-04-23 19:00 (5891 d 05:19 ago) – Posting: # 5204
Views: 10,083

Dear D. Labes,

We have just released a new version of the PK package (1.2-2) which, among other things, now allows a more natural estimation of individual PK parameters.

Besides

time <- c(0,0.25,0.5,0.75,1,1.5,2,2.5,3,4,5,6)

conc <- c(0,5.67,20.6,28.7,22.5,17.4,17.7,13.4,11.0,8.23,5.14,2.84)

auc(conc,time,design='complete')

which produces a point estimate of the AUC one now can also use for example

nca(conc,time, n.tail=3, dose=100, design='complete')

to obtain other parameters of interest.

Note that both functions do not provide standard errors and confidence intervals at the moment.

Best,

Jack

Complete thread:

Trapezoidal rule - Hmisc d_labes 2010-04-19 13:41 [🇷 for BE/BA]
- Trapezoidal rule - PK Helmut 2010-04-20 12:53
  - package PK d_labes 2010-04-20 14:35
    - package PK Jack 2010-04-20 15:21
    - Syntax... Helmut 2010-04-20 15:31
    - package PKJack 2010-04-23 17:00
      - package PK d_labes 2010-04-26 08:04