Number of subjects [Power / Sample Size]

posted by olacy – Hungary, 2007-02-02 16:10 (6264 d 14:53 ago) – Posting: # 503
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Dear All,

How can I argue for the increased number of subjects in case of a highly variable drug? To set the power to 90% (from 80%) or should I refer to the very high CV% (for example 45%, power=80%)?
Which is less risky? I think the latter one.
I think that the power could not be changed subsequently if the biostudy failed because of 90% power but would pass with 80%.
Please confirm and advise.
When is it needed to increase the power to 90%?
Thanks in advance!

Best regards,
olacy

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