Bioequivalence and Bioavailability Forum

partial replicate? [Software]

posted by d_labes  – Berlin, Germany, 2010-03-22 10:50 (5937 d 13:51 ago) – Posting: # 4955
Views: 13,452

Dear dixit, ambati?,

I guess your design is eventually a partially replicate design (only Reference replicated, RTR/TRR/RRT)?

In that design one would expect sigma²_T not identifiable because Test was not administered replicated.
Then using the FDA code results in over-specifying the model. See this thread.
One hint for this is the result for residual Test in your output above.

But don't ask me for an other implementation in SAS for that design. I was up to now not able to figure it out and had also not been successful in finding a reference. Sorry .

Complete thread:

• Convergence problem in PROC MIXED dixit 2010-03-21 10:19 [Software] 
  • Convergence problem in PROC MIXED ElMaestro 2010-03-21 11:35
    • Convergence problem in PROC MIXED dixit 2010-03-22 06:26
      • Convergence problem in PROC MIXED ElMaestro 2010-03-22 08:21
        • Convergence problem in PROC MIXED dixit 2010-03-23 19:15
          • Convergence problem in PROC MIXED ElMaestro 2010-03-23 20:29
            • Convergence problem in PROC MIXED dixit 2010-03-24 15:09
              • Convergence problem in PROC MIXED ElMaestro 2010-03-25 07:44
              • Bogus PROC MIXED/FDA d_labes 2010-03-25 09:15
                • Bogus PROC MIXED/FDA ElMaestro 2010-03-25 10:42
                  • Bogus PROC MIXED/FDA d_labes 2010-03-26 09:45
          • Convergence problem in PROC MIXED shri 2010-04-05 08:01
      • partial replicate?d_labes 2010-03-22 09:50