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Registereffect of alcohol on drug bioavailability [Study Performance]
posted by Helmut 
– Vienna, Austria, 2010-02-06 14:32 (5975 d 09:00 ago) – Posting: # 4723
Views: 14,944
Dear Niraj!
Not interested in the opinions of other forum members?
Mainly by increasing GI blood flow. Spirits may even lead to a pyloric spasm which will delay absorption (decrease or increase of absorption based on the properties of the drug). There is also the possibility of an interaction with metabolizing enzymes (if your drug contains an aliphatic OH-radical competitive with alcohol dehydrogenase), etc… A better release of the API from the formulation (enhanced solubility) I would consider a myth, because alcohol is one the few drugs which are very rapidly absorbed from the stomach – so nothing will be left before the absorption from the formulation will have a chance to start.
❝ Dear HS,
^^Not interested in the opinions of other forum members?
❝ please tell me how alcohol will affect drug bioavailability?
Mainly by increasing GI blood flow. Spirits may even lead to a pyloric spasm which will delay absorption (decrease or increase of absorption based on the properties of the drug). There is also the possibility of an interaction with metabolizing enzymes (if your drug contains an aliphatic OH-radical competitive with alcohol dehydrogenase), etc… A better release of the API from the formulation (enhanced solubility) I would consider a myth, because alcohol is one the few drugs which are very rapidly absorbed from the stomach – so nothing will be left before the absorption from the formulation will have a chance to start.
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Helmut Schütz
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- effect of alcohol on drug bioavailability Dr.Niraj Limbachiya 2010-02-06 09:15 [Study Performance]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- effect of alcohol on drug bioavailabilityHelmut 2010-02-06 13:32
- effect of alcohol on drug bioavailability Ohlbe 2010-02-07 23:54
- effect of alcohol on drug bioavailability Helmut 2010-02-07 23:58
- effect of alcohol on drug bioavailability Ohlbe 2010-02-08 00:36
- effect of alcohol on drug bioavailability Helmut 2010-02-08 14:08
- effect of alcohol on drug bioavailability Ohlbe 2010-02-08 17:01
- effect of alcohol on drug bioavailability Helmut 2010-02-08 17:07
- effect of alcohol on drug bioavailability ElMaestro 2010-02-08 18:19
- effect of alcohol on drug bioavailability mvgchakravarthi 2010-02-15 17:41
- exact definitions ElMaestro 2010-02-15 18:31
- exact definitions mvgchakravarthi 2010-02-16 15:32
- exact definitions Ohlbe 2010-02-16 17:11
- exact definitions mvgchakravarthi 2010-02-16 15:32
- exact definitions ElMaestro 2010-02-15 18:31
- effect of alcohol on drug bioavailability mvgchakravarthi 2010-02-15 17:41
- effect of alcohol on drug bioavailability Ohlbe 2010-08-05 00:27
- effect of alcohol on drug bioavailability ElMaestro 2010-02-08 18:19
- effect of alcohol on drug bioavailability Helmut 2010-02-08 17:07
- effect of alcohol on drug bioavailability Ohlbe 2010-02-08 17:01
- effect of alcohol on drug bioavailability Helmut 2010-02-08 14:08
- effect of alcohol on drug bioavailability Ohlbe 2010-02-08 00:36
- effect of alcohol on drug bioavailability Helmut 2010-02-07 23:58
- effect of alcohol on drug bioavailability Ohlbe 2010-02-16 17:17
- effect of alcohol on drug bioavailability ElMaestro 2010-02-16 21:11
- effect of alcohol on drug bioavailability Ohlbe 2010-02-07 23:54
- effect of alcohol on drug bioavailabilityHelmut 2010-02-06 13:32
Ing. Helmut Schütz