Bioequivalence and Bioavailability Forum

Dear HS,

❝ Any specific questions? Which version of WinNonlin are you using (WinNonlin 5.x, Phoenix 6.x)?

I am using WinNonlin 5.2,

❝ I guess you have read the User's Guide (WNL v5.2.1 page 172, Phoenix 6.0 page 280, Phoenix 6.1 page 277).

❝ in 'Dosing Regimen' check ☑ 'Steady state', Dose 1, Time of Last Dose 0, Tau 24

❝ in 'Model Options' > 'NCA Settings' > 'Calculation Method' > Linear Trapezoidal (Linear/Log Interpolation)

I have read User's Guide (WinNonlin5.2) but not get required answer.

Below I have given data of 1st subject of period 1 only. I have used above steps,
DATA -
Time Point  Concentration
      0           0
     12          28.293
     24          45.195
     36          50.02
     48          49.943
     60          43.504
     72          54.623
     84          49.127
     96          55.6
     96.5        47.275
     97          43.922
     97.5        41.548
     98          55.969
     98.5        45.51
     99          54.26
     99.5        76.275
    100          76.665
    100.5        82.121
    101          75.479
    101.5        81.925
    102          93.584
    104          75.287
    108          52.053
    112          33.08
    114          27.296
    120          12.486
    132           5.6

'Dosing Regimen' check ☑ 'Steady state', Dose 35, Time of Last Dose 96, Tau 12
in 'Model Options' > 'NCA Settings' > 'Calculation Method' > Linear Trapezoidal (Linear/Log Interpolation)

Results I got,
Cmin        41.548
AUCtau     801.3215
AUClast   1259.8256
Lambda_z     0.0967
Tmin        97.5
Cavg        66.7768
Fluctuation 77.9253

Kindly tell me, whether my results are correct or not?

Thanks and Regards,

Naresh Shirsath