Bioequivalence and Bioavailability Forum

Dear D. Labes,

❝ once again: Where does the sample size come from?

❝ Can you please explain in a little bit more detail? df, design constant,

❝ exact or with non-central t? Or sample size for 2x2 multiplied by 0.75?

Oh, the latter. I just realize, that the method may not be applicable for the partial replicate.*

❝ Don't call me obtrusive nitpicker .

No, no; I like that.

❝ I'm interested in including this design (RRT, RTR, TRR, a 2-treatment-3-

❝ sequence-3-period design) into my "eierlegende wollmilchsau" but have

❝ not found any hint about sample size for ABE within that design up to now.

❝ Do you have any reference for me?

Based on Table 3, 75% of a 2×2 and ~125% of a 2×4 replicate seems to apply as well.

---

• Hyslop T, Iglewicz B. Alternative Cross-over Designs for Individual Bioequivalence. Proceedings of the Annual Meeting of the American Statistical Association, August 5-9, 2001. online resource