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RegisterOld farts [General Statistics]
Dear D. Labes and Helmut,
thank you for sharing your experienced viewpoint. As you, I have never used models including simple carryover effect and I'm not pursuing this approach.
I was thinking again about the interpretation of sequence effect in designs with more than two treatments and an equal number of periods. Probably, if we assume that carryover of higher order are extremely unlikely, its interpretation is analogous to that given in 2x2 design.
As regards the inclusion of sequence effect in BE studies, I think that the book by Jones and Kenward [*] shows an interesting feature. This variable is not included in any model until the last chapter (7. Bioequivalence trials), where it is stated: "Following common practice we will also fit a sequence or group effect" (section 7.1). What I am really interested in is the rationale behind this "common practice".
Thank you again for your help.
[*] B. Jones, M.G. Kenward, "Design and Analysis of Cross-Over Trials", Second edition, Chapman & Hall/CRC 2003.
thank you for sharing your experienced viewpoint. As you, I have never used models including simple carryover effect and I'm not pursuing this approach.
I was thinking again about the interpretation of sequence effect in designs with more than two treatments and an equal number of periods. Probably, if we assume that carryover of higher order are extremely unlikely, its interpretation is analogous to that given in 2x2 design.
As regards the inclusion of sequence effect in BE studies, I think that the book by Jones and Kenward [*] shows an interesting feature. This variable is not included in any model until the last chapter (7. Bioequivalence trials), where it is stated: "Following common practice we will also fit a sequence or group effect" (section 7.1). What I am really interested in is the rationale behind this "common practice".
Thank you again for your help.
[*] B. Jones, M.G. Kenward, "Design and Analysis of Cross-Over Trials", Second edition, Chapman & Hall/CRC 2003.
—
Kind regards,
Stefano
Kind regards,
Stefano
Complete thread:
- Is the sequence effect mandatory? vezz 2009-12-09 21:52 [General Statistics]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Is the sequence effect mandatory? Pankaj Mishra 2009-12-10 07:21
- Sequence effect and 90% CI d_labes 2009-12-10 09:24
- Is the sequence effect mandatory? d_labes 2009-12-10 09:01
- Is the sequence effect mandatory? vezz 2009-12-10 11:02
- Treatment by period interaction d_labes 2009-12-10 16:43
- Old farts Helmut 2009-12-10 16:55
- Old fartsvezz 2009-12-10 18:10
- New brooms Helmut 2009-12-10 19:19
- Give sequence a chance d_labes 2009-12-11 09:42
- Give history a chance Helmut 2009-12-11 13:40
- Old farts? d_labes 2009-12-11 09:09
- Young farts... Helmut 2009-12-11 13:51
- Old fartsvezz 2009-12-10 18:10
- Old farts Helmut 2009-12-10 16:55
- Treatment by period interaction d_labes 2009-12-10 16:43
- Is the sequence effect mandatory? vezz 2009-12-10 11:02
- Is the sequence effect mandatory? Pankaj Mishra 2009-12-10 07:21
Ing. Helmut Schütz