Bioequivalence and Bioavailability Forum

Dear d_labes,

Thank you for your answer.
Really, I try to analyze a 2x2 crossover study (non replicated), where each volunteers get each formulas, but each formulas only once. So, TR and RT are the sequences in periods.
I understand (?) that there is only one intra-subject CV for each PK parameters (e.g. AUC0-t), because each subjects get both formulas, so the intra-CV gives information about the variability of subjects AUC0-t in formulas point of view.
But inter-CV get information about the variability of subjects AUC0-t for formulas in separated way: one inter-subject CV for the T formula and one other for the R formula. It is right idea or not?

kvitamin

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Edit: Full quote removed. Please delete anything from the text of the original poster which is not necessary in understanding your answer; see also this post! [Ohlbe]