Bioequivalence and Bioavailability Forum

Dear Ashok!

❝ Is there a way to calculate the Intrasubject CV (ISCV) when we know the

❝ T/R ratio and confidence interval (power 0.8; level of significance 5%).

Yes. You don't need the power in such a calculation - only the CI and the study's sample size (preferably the number of subjects / sequence also). T/R is optional. See these threads:

• #338
  
• #3009

David Dubins' FARTSSIE has an option to calculate CV_intra from the point estimate and the CI for balanced (=equal number of subjects in each sequence) studies: Sheet [Bioequivalence, Crossover], Button ISV from Published Point Estimate and CI.

If you don't trust in M$-Excel, you can do a manual calculation as well - see one of my lectures (slides 12-15).