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Back to the forum  2018-07-20 18:59 CEST (UTC+2h)

half-life in multiple-dosed steady-state BE/BA study? [NCA / SHAM]

posted by yjlee168 Homepage - Kaohsiung, Taiwan, 2009-07-14 14:16  - Posting: # 3954
Views: 8,705

Dear All,

I just like to know if it is reasonable to estimate lambdaz when doing data analysis of a multiple-dosed steady-state (SS) BE/BA study. It is because we just collect the plasma/blood sample within one dosing interval (Tau) at steady-state in a multiple-dosed BE/BA study. It looks like there is no such terminal phase at all in multiple-dosed BE/BA study. If it is not reasonable, is there any way to estimate the elimination rate constant (kel), half-life, Vss or the accumulation index? In WinNonlin v5.x, lambdaz still needs to be estimated first for further calculations of other NCA parameters. Thanks in advanced.

All the best,
---Yung-jin Lee
[image]bear v2.8.3-1:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan http://pkpd.kmu.edu.tw/bear
Download link (updated) -> here

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