Bioequivalence and Bioavailability Forum

Main page Policy/Terms of Use Abbreviations Latest Posts

 Log-in |  Register |  Search

Back to the forum  Query: 2018-01-16 10:29 CET (UTC+1h)

half-life in multiple-dosed steady-state BE/BA study? [NCA / SHAM]

posted by yjlee168 Homepage - Kaohsiung, Taiwan, 2009-07-14 14:16  - Posting: # 3954
Views: 6,898

Dear All,

I just like to know if it is reasonable to estimate lambdaz when doing data analysis of a multiple-dosed steady-state (SS) BE/BA study. It is because we just collect the plasma/blood sample within one dosing interval (Tau) at steady-state in a multiple-dosed BE/BA study. It looks like there is no such terminal phase at all in multiple-dosed BE/BA study. If it is not reasonable, is there any way to estimate the elimination rate constant (kel), half-life, Vss or the accumulation index? In WinNonlin v5.x, lambdaz still needs to be estimated first for further calculations of other NCA parameters. Thanks in advanced.

All the best,
---Yung-jin Lee
[image]bear v2.8.3:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan
Download link (updated) -> here

Complete thread:

Back to the forum Activity
 Mix view
Bioequivalence and Bioavailability Forum | Admin contact
17,667 Posts in 3,778 Threads, 1,101 registered users;
30 users online (0 registered, 30 guests).

In matters of style, swim with the current;
in matters of principle, stand like a rock.    Thomas Jefferson

BEBAC Ing. Helmut Schütz