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Registerhalf-life in multiple-dosed steady-state BE/BA study? [NCA / SHAM]
posted by yjlee168 
– Kaohsiung, Taiwan, 2009-07-14 16:16 (5398 d 04:45 ago) – Posting: # 3954
Views: 16,412
Dear All,
I just like to know if it is reasonable to estimate lambdaz when doing data analysis of a multiple-dosed steady-state (SS) BE/BA study. It is because we just collect the plasma/blood sample within one dosing interval (Tau) at steady-state in a multiple-dosed BE/BA study. It looks like there is no such terminal phase at all in multiple-dosed BE/BA study. If it is not reasonable, is there any way to estimate the elimination rate constant (kel), half-life, Vss or the accumulation index? In WinNonlin v5.x, lambdaz still needs to be estimated first for further calculations of other NCA parameters. Thanks in advanced.
I just like to know if it is reasonable to estimate lambdaz when doing data analysis of a multiple-dosed steady-state (SS) BE/BA study. It is because we just collect the plasma/blood sample within one dosing interval (Tau) at steady-state in a multiple-dosed BE/BA study. It looks like there is no such terminal phase at all in multiple-dosed BE/BA study. If it is not reasonable, is there any way to estimate the elimination rate constant (kel), half-life, Vss or the accumulation index? In WinNonlin v5.x, lambdaz still needs to be estimated first for further calculations of other NCA parameters. Thanks in advanced.
—
All the best,
-- Yung-jin Lee
bear v2.9.1:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here
All the best,
-- Yung-jin Lee
bear v2.9.1:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here
Complete thread:
- half-life in multiple-dosed steady-state BE/BA study?yjlee168 2009-07-14 14:16
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- half-life in steady state; WinNonlin Helmut 2009-07-15 15:09
- no lambda(z), no NCA? yjlee168 2009-07-16 11:53
- NCA without lambda(z) Helmut 2009-07-16 14:06
- No rule is the rule - lambda(z) of MD BE yjlee168 2009-07-16 22:17
- NCA without lambda(z) Helmut 2009-07-16 14:06
- Distinguish accumulation oksanachlebko 2018-01-05 00:10
- no lambda(z), no NCA? yjlee168 2009-07-16 11:53
- half-life in steady state; WinNonlin Helmut 2009-07-15 15:09
Ing. Helmut Schütz