half-life in multiple-dosed steady-state BE/BA study? [NCA / SHAM]

posted by yjlee168 Homepage – Kaohsiung, Taiwan, 2009-07-14 14:16 (4017 d 21:28 ago) – Posting: # 3954
Views: 12,944

Dear All,

I just like to know if it is reasonable to estimate lambdaz when doing data analysis of a multiple-dosed steady-state (SS) BE/BA study. It is because we just collect the plasma/blood sample within one dosing interval (Tau) at steady-state in a multiple-dosed BE/BA study. It looks like there is no such terminal phase at all in multiple-dosed BE/BA study. If it is not reasonable, is there any way to estimate the elimination rate constant (kel), half-life, Vss or the accumulation index? In WinNonlin v5.x, lambdaz still needs to be estimated first for further calculations of other NCA parameters. Thanks in advanced.

All the best,
-- Yung-jin Lee
bear v2.8.8:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan http://pkpd.kmu.edu.tw/bear
Download link (updated) -> here

Complete thread:

Activity
 Admin contact
20,834 posts in 4,358 threads, 1,449 registered users;
online 21 (2 registered, 19 guests [including 11 identified bots]).
Forum time: 11:44 CEST (Europe/Vienna)

[Those] who have an excessive faith in their theories or in their
ideas are not only poorly disposed to make discoveries, but they
also make very poor observations.    Claude Bernard

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5