Bioequivalence and Bioavailability Forum

population parameter [Power / Sample Size]

posted by martin  – Austria, 2009-05-05 23:32 (6243 d 22:37 ago) – Posting: # 3650
Views: 11,771

Dear EM!

a larger sample size will result in a narrower confidence interval for the unknown population parameter (rule of thumb: quadruple the sample size will double precision). you choose R/T=95% and not R/T=100% as expected population parameter for your simulations and the narrower confidence intervals (for the expected true ratio of R/T=95%) for larger sample sizes will give you the results observed in your simulation study. just use R/T=100% as population parameter (i.e. assuming perfect BE ) and differences in power will be smaller.

hope this helps

martin

Complete thread:

• Power with a Danish twist ElMaestro 2009-05-05 19:49 [Power / Sample Size] 
  • population parametermartin 2009-05-05 21:32
    • population parameter ElMaestro 2009-05-05 21:48
      • population parameter martin 2009-05-05 22:59
  • Wrong Question Answer in Danish d_labes 2009-05-08 09:49
    • Danish numbers d_labes 2009-05-08 15:53
      • Danish numbers ElMaestro 2009-05-08 20:19
  • Power with a Danish twist Helmut 2009-05-08 13:23
    • Power with a Danish twist d_labes 2009-05-08 16:06
      • Power with a Danish twist Helmut 2009-05-08 16:15
    • Power with a Danish twist ElMaestro 2009-05-08 19:40
  • Power with a Danish twist Helmut 2009-05-08 16:56
    • Power with a Danish twist ElMaestro 2009-05-08 19:17