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RegisterExpected difference in formulations [Power / Sample Size]
Dear Dr. Helmut,
Even if we account for CV as you have discussed, How could we account for the difference in the formulation for test and reference to calculate the sample size.
n > [t(alpha, 2n-2) + t(beta, 2n-2)]2 [CV/(20-eta)]2,
where eta = 100 x theta/µR = 100 x (µT - µR)/ µR
EQN is referred from ANVISA.
With regards,
D.Ahmed
Even if we account for CV as you have discussed, How could we account for the difference in the formulation for test and reference to calculate the sample size.
n > [t(alpha, 2n-2) + t(beta, 2n-2)]2 [CV/(20-eta)]2,
where eta = 100 x theta/µR = 100 x (µT - µR)/ µR
EQN is referred from ANVISA.
With regards,
D.Ahmed
Complete thread:
- Pilot Study always needed? venu 2006-10-30 11:33 [Power / Sample Size]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Pilot Study not always needed! Helmut 2006-10-30 13:09
- Expected difference in formulationsAhmed meeran 2006-11-01 12:37
- Expected difference in formulations Helmut 2006-11-01 14:56
- Pilot Study not always needed! youri 2006-12-12 17:12
- CV Estimation from CI... Helmut 2006-12-12 17:47
- Expected difference in formulationsAhmed meeran 2006-11-01 12:37
- Pilot Study not always needed! Helmut 2006-10-30 13:09
Ing. Helmut Schütz