Calculation of AUC0-72 [NCA / SHAM]

posted by d_labes  – Berlin, Germany, 2009-01-26 16:57  – Posting: # 3125
Views: 18,046

Dear Helmut,

» sorry for the late response – I was driven by discussions about the drafted European BE-Guideline. :-D

"Late is not too late".

I am with you if the values in the last part of the concentration time course are <LOQ. But I think it's different with missing values (vial broken or so) especially in case of long half life drugs.

Because time points are spread occasionally with 24h in the last part, there may be a considerable portion of AUC missing.

» I wouldn’t start trying to get an estimate of C72.

Is this sentence then furthermore your opinion?

Regards,

Detlew

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