Bioequivalence and Bioavailability Forum • Degenerated trapezoid ;-)

Degenerated trapezoid ;-) [🇷 for BE/BA]

posted by d_labes – Berlin, Germany, 2008-12-18 09:25 (6382 d 17:47 ago) – Posting: # 2937
Views: 11,776

Dear Yung-jin,

thanks for replying.

❝ [...] The time zero was absolutely included. The first piece AUC

❝ is not exactly a trapezoid, but a triangle. [...]

So it should be! But sorry I cannot recover this in your output on the Bear homepage.
Here a piece of your NCA_PK.txt

<< NCA Output:- Subject# 1  (Ref.)>>

--------------------------------------------------------------------------

   subj  time   conc   AUC(0-t)    AUMC(0-t)

1     1  0.25   36.1     0.0000     0.000000

2     1  0.50  125.0    20.1375     8.940625

3     1  0.75  567.0   106.6375    69.909375

4     1  1.00  932.0   294.0125   239.565625

[...]

Seems to me: No triangle from time zero to time 0.25 h :-P

:
Or miss I some piece?

For that data I have calculated AUC(0-t)=14445.275.

Yours is AUC(0-t)=14440.76. Triangle (some sort of degenerate trapezoid ;-)

) from 0-0.25h=0.25*36.1/2=4.5125.
Sum both and you get mine.

BTW: The half-life calculation I was able to verify exactly using SAS code for the ARS method :ok:

—
Regards,

Detlew

Complete thread:

AUC in Bear d_labes 2008-12-15 15:19 [🇷 for BE/BA]
- AUC in Bear yjlee168 2008-12-17 18:57
  - Degenerated trapezoid ;-)d_labes 2008-12-18 08:25
    - Degenerated trapezoid ;-) yjlee168 2008-12-18 08:44
      - Bear at Home d_labes 2008-12-18 09:02
        
        Bear at Home yjlee168 2008-12-18 09:47
        
        Bear - statistical summary d_labes 2008-12-18 11:46
        
        Bear - statistical summary yjlee168 2008-12-18 12:13