Tmax [General Statistics]
Dear shri!
Not the ‘rest of the PK parameters’!
There are many different descriptive statistics that can be chosen as a measurement of the central tendency of data (e.g., arithmetic, geometric, harmonic mean, median, mode,…)
Based on assumptions of the underlying distribution, different averages are used:
These distributional assumptions lead also to different statistical models if comparisons are performed:
❝ [...] in place of the "geometric least square mean", which is performed on the rest of the PK parameters analyses?
Not the ‘rest of the PK parameters’!
There are many different descriptive statistics that can be chosen as a measurement of the central tendency of data (e.g., arithmetic, geometric, harmonic mean, median, mode,…)
Based on assumptions of the underlying distribution, different averages are used:
AUC:
geometric meanAe:
arithmetic meantmax:
mediant½:
harmonic mean (although geometric mean used by some colleagues)These distributional assumptions lead also to different statistical models if comparisons are performed:
AUC:
multiplicative model (or additive on log-transformed data)Ae:
additive modeltmax:
nonparametric methodst½:
no idea (suggestions? randomization test?)—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Tmax shri 2008-12-12 08:06 [General Statistics]
- Tmax median; not again... Jaime_R 2008-12-12 10:28
- TmaxHelmut 2008-12-12 19:31
- Urinary PK parameters and CLr vezz 2009-12-11 15:59
- Urinary PK parameters and CLr Helmut 2009-12-11 17:02
- Urinary PK parameters and CLr vezz 2009-12-13 07:31
- Urinary PK parameters and CLr Helmut 2009-12-11 17:02
- Urinary PK parameters and CLr vezz 2009-12-11 15:59