90% CIs for BE? [🇷 for BE/BA]

posted by Helmut Homepage – Vienna, Austria, 2008-11-17 14:30 (5610 d 17:46 ago) – Posting: # 2688
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Dear Yung-jin,

I agree with ElMaestro. BTW, Westlake’s CI should never be used and thrown into the statistical garbage collection because it obscures information about the location of the difference (I have not the slightest idea why it’s still used in WinNonlin).
Example from a study with low variability (CVintra 8.63%, n=12):

Shortest CI:   100.54% – 113.52% (PE 106.84%)
Westlake’s CI:  88.06% – 111.94%

According to the original paper of Westlake* the CI would be stated as ±11.94%:not really: You have no clue that the BA of the test formulation is statistically significant (though not clinically relevant) higher than the reference’s.



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