Calculation of AUCt, AUCall, AUCinf... [NCA / SHAM]

posted by Helmut Homepage – Vienna, Austria, 2008-10-10 19:48 (5648 d 14:44 ago) – Posting: # 2507
Views: 25,316

Dear Jungmin!

❝ I always appreciate informations on this web site.


Thanks!

❝ I have calculated AUCinf-pred (Method #5) according to your explanations.

❝ But, I couldn't get the same result as you did.


Oops!

❝ These values are not same your values.

❝ - AUCinf-pred of ref : 405.98213(I) vs 405.93053 (yours)

❝ - AUCinf-pred of test : 383.75213(I) vs 383.74829 (yours)


❝ There's some severe mistakes in my calculation? (please check..)


You are absolutely correct; your values are right, whereas mine are wrong. Updated table:
Method 5
Extrapolation from tlast to t=∞ based on the predicted concentration Clast (AUCinf, AUCinf-pred)
┌───────────┬───────────┬────────┬────────┐
│   ref     │   test    │  T/R   │ % Bias │
├───────────┼───────────┼────────┼────────┤
│ 405.98213 │ 383.75123 │ 94.52% │ -0.50% |
└───────────┴───────────┴────────┴────────┘


❝ And, could you please explain why AUCinf-pred is not a same value between us?


Stupidity?
I’m greateful for your correction – sometimes I’m hit by the devil of copy & paste… :angry:

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