lambda_z estimation [🇷 for BE/BA]

posted by Aceto81 – Belgium, 2008-09-25 12:56 (6466 d 02:13 ago) – Posting: # 2401
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❝ I do not own WINNONLIN, but I suggest that the point tmax, Cmax should not be included in the terminal part.

❝

❝ I further suggest that the TTT (two-times tmax) rule should be implemented to restrict the number of points in the terminal part, provided that at least 3 points are available.

❝ See this thread for the TTT rule.

❝

❝ May be the Akaike information criterion AIC (especially the AICc, small sample formula) is a better choice than adj. RSquare.


If the Cmax may not be included, this explains the difference between the R code and WinNonlin.
If you change
   for (i in (nrow(dat)-3):which.max(dat$conc))
to
   for (i in (nrow(dat)-3):(which.max(dat$conc)+1))
then Cmax is excluded.

And you would get the same result as WinNonlin.

Ace
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