Calculation of AUC0-72 [NCA / SHAM]

posted by d_labes  – Berlin, Germany, 2008-09-05 15:00  – Posting: # 2323
Views: 18,583

Dear Ohlbe, dear Jaime, dear all,

I would like to discuss this a bit further.
How do you act in a truncated setting if the last sample is missing? Or if some subject has conc. <LOQ due to faster kinetics?

Omit this subject from the analysis? Or try to extrapolate to t=72h?

If extrapolation is an option for you: how?
Using an estimate of lamdaZ or by the last preceding 2 points?

Regards,

Detlew

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