Regarding Steady state study in BE studies [Design Issues]

posted by VijithRoy – India, 2020-11-20 04:28 (65 d 18:46 ago) – Posting: # 22071
Views: 345


Usually steady state techniques are conducted to maintain constant free drug in plasma with equal elimination. It applies for drugs which come under Time dependent activity.

My question,

1. In what case or particular class of drugs we should go for steady state studies in comparitive BA or BE studies?

2. How does Vidagliptin/metformin (fdc) comes under steady state studies?

Appreciating in advance for your response.

Thank you.

With warm regards,
T. Vijith

Complete thread:

 Admin contact
21,310 posts in 4,445 threads, 1,489 registered users;
online 2 (0 registered, 2 guests [including 2 identified bots]).
Forum time: Sunday 23:14 CET (Europe/Vienna)

Every man gets a narrower and narrower field of knowledge
in which he must be an expert in order to compete with other people.
The specialist knows more and more about less and less
and finally knows everything about nothing.    Konrad Lorenz

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz