Parallel design from crossover CV [Power / Sample Size]

posted by arl_stat – India, 2020-10-14 06:39 (49 d 14:01 ago) – Posting: # 21996
Views: 447

Greetings to all !!

Hope all of you are safe in this pandemic situation:-).

Mostly in public domain, the inter subject CV of drug is not mentioned. Either intra-subject cv or confidence interval ranges are mentioned. So can we use this intra-subject CV to estimate sample size for parallel study design?

Is there any formula to calculate inter-subject CV using 90% confidence interval ranges and number of subjects?

First can we calculate the sample size of 2 way crossover study design and then double the subjects and finalize the sample size for parallel study design?

Please suggest.

Stay Safe.

Thank You :-)

Edit: Category changed; see also this post #1. Subject line changed; see also this post #2[Helmut]

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