Bioequivalence and Bioavailability Forum • Mea culpa!

Mea culpa! [Power / Sample Size]

posted by Helmut – Vienna, Austria, 2020-05-04 14:40 (1446 d 03:54 ago) – Posting: # 21395
Views: 8,144

Hi ElMaestro,

❝ the powerTOST package is excellent …

THX!

❝ … and I am not myself a very experienced user (yet) as I tend to rely on much less reliable code of my own making :-D

Never trust in any piece of software you haven't written yourself
(and even then you should be cautious…)

❝ So forgive me I am asking: I think the OP implied a partial replicate. TRR/RRT/RTR is not 3x6x3 but rather 2(trts)x3(seqs)x3(pers), …

Oops! You are absolutely right.

❝ ❝ 3 way crossover, reference replicate

❝ … is there a reason to plug in 3x6x3 in your code?

I screwed up! Of course, not a 3-period Williams’ design. Hence,

library(PowerTOST) round(100 * CVfromCI(lower = 0.9625, upper = 1.2511, n = 41, design = "2x3x3"), 2)

and

Unbalanced 2x3x3 design. n(i)= 14/14/13 assumed. [1] 42.97

That’s reasonably close to the 42.6% given in the PAR. Sorry for the confusion caused!

@Alyssa: Can you please check whether the expanded limits are also given in the PAR? Based on CV_wR 42.6% they should be close to

round(100 * scABEL(CV = 42.6 / 100), 1) lower upper 73.3 136.4

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Complete thread:

Sample size calculation (Pilot study result vs literature) Alyssa 2020-05-04 04:35
- Sample size calculation (Pilot study result vs literature) Dr_Dan 2020-05-04 08:46
  - Sample size calculation (Pilot study result vs literature) Alyssa 2020-05-04 09:26
- Estimation of CVw and/or CVwR Helmut 2020-05-04 12:07
  - Estimation of CVw and/or CVwR ElMaestro 2020-05-04 12:14
    - Mea culpa!Helmut 2020-05-04 12:40
      - It must be Myco ElMaestro 2020-05-04 13:46
        
        It is, it is! Helmut 2020-05-04 14:07
        
        It is.... Alyssa 2020-05-05 05:00
        
        Tutorial Helmut 2020-05-05 12:45
        
        Tutorial Alyssa 2020-05-08 06:48
        
        library d_labes 2020-05-08 11:16
        Tutorial (from the start) Helmut 2020-05-08 13:08
        
        Tutorial (from the start) Alyssa 2020-05-12 04:05
        
        Tracking down error Helmut 2020-05-12 11:49
        
        Tracking down error: stringsAsFactors d_labes 2020-05-13 11:34
        
        R <4.0.0 Helmut 2020-05-13 12:07
        
        R <4.0.0 ElMaestro 2020-05-13 14:18
        
        R <4.0.0? Helmut 2020-05-13 14:21
        
        PowerTOST’s functions with as.character(design) d_labes 2020-05-13 18:50
        
        PowerTOST’s functions with as.character(design) Helmut 2020-05-13 18:55
        
        Tracking down error Alyssa 2020-05-15 05:08
        
        All’s well that ends well. Helmut 2020-05-15 10:52