A vs B [Design Issues]

posted by mittyri – Russia, 2020-02-03 22:05 (1515 d 12:55 ago) – Posting: # 21136
Views: 2,954

Hi John,

citing our Hero:

If one is really interested in λz and has no SD-phase in the study, sampling should continue until concentrations from previous doses are washed out – I would expect any estimate within the MD-profile to be biased towards faster elimination.

❝ I have seen both designs but I (and my former bosses) prefer method A. The only drawback I see from A is it takes longer time.


why does A take longer time?


Edit: Changed to internal link; see also this post #7[Helmut]

Kind regards,
Mittyri

Complete thread:

UA Flag
Activity
 Admin contact
22,957 posts in 4,819 threads, 1,636 registered users;
107 visitors (0 registered, 107 guests [including 4 identified bots]).
Forum time: 11:01 CET (Europe/Vienna)

With four parameters I can fit an elephant,
and with five I can make him wiggle his trunk.    John von Neumann

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5