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RegisterLeads to a (pseudo-) period effect ? [Bioanalytics]
Dear all
I think you should define which effects (random, i.e. variability by chance or systematic, i.e. bias due to e.g. degrading analytical performance, stock solution etc.) you assume and which of these you can rule out by looking at results for QCs, comparing calibration functions etc. That is what all the quality control for your method is done for.
Without that defined it's hard to jump to conclusions regarding the concentrations you determine, let alone the pk parameters you calculate from these.
If the day-to-day performance of your analytical method is that bad, I wouldn't do any volunteer samples, but go back to the lab and improve your method. No doubt, the least variability/bias will be introduced by the setup Helmut lined out. But I don't think that a good analytical method and a good analytical chemist can't handle the exception from this rule (if necessary and justified)...
I think you should define which effects (random, i.e. variability by chance or systematic, i.e. bias due to e.g. degrading analytical performance, stock solution etc.) you assume and which of these you can rule out by looking at results for QCs, comparing calibration functions etc. That is what all the quality control for your method is done for.
Without that defined it's hard to jump to conclusions regarding the concentrations you determine, let alone the pk parameters you calculate from these.
If the day-to-day performance of your analytical method is that bad, I wouldn't do any volunteer samples, but go back to the lab and improve your method. No doubt, the least variability/bias will be introduced by the setup Helmut lined out. But I don't think that a good analytical method and a good analytical chemist can't handle the exception from this rule (if necessary and justified)...
—
Kindest regards, nobody
Kindest regards, nobody
Complete thread:
- Crossover: samples of p1 and p2 in different batches? Ravuri sindhura 2019-09-18 19:16
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Crossover: samples of p1 and p2 in different batches? dshah 2019-09-19 09:16
- Leads to a (pseudo-) period effect Helmut 2019-09-19 15:33
- Leads to a (pseudo-) period effect ? Ohlbe 2019-09-19 15:50
- Leads to a (pseudo-) period effect ? Helmut 2019-09-19 15:59
- Leads to a (pseudo-) period effect ?nobody 2019-09-19 16:21
- Almost entirely OT Helmut 2019-09-19 17:22
- Almost entirely OT nobody 2019-09-19 17:46
- Completely OT Helmut 2019-09-19 18:08
- Almost entirely OT nobody 2019-09-19 17:46
- Almost entirely OT Helmut 2019-09-19 17:22
- Leads to a (pseudo-) period effect ? dshah 2019-09-20 07:52
- Leads to a (pseudo-) period effect ? nobody 2019-09-20 08:00
- Run ≠ batch? Helmut 2019-09-20 09:42
- Run ≠ batch Ohlbe 2019-09-20 10:37
- Run ≠ batch? dshah 2019-09-23 07:43
- Run ≠ batch? nobody 2019-09-23 08:36
- Leads to a (pseudo-) period effect ?nobody 2019-09-19 16:21
- Leads to a (pseudo-) period effect ? Helmut 2019-09-19 15:59
- Leads to a (pseudo-) period effect Ravuri sindhura 2019-09-23 13:04
- Leads to a (pseudo-) period effect ? Ohlbe 2019-09-19 15:50
- Leads to a (pseudo-) period effect Helmut 2019-09-19 15:33
- Crossover: samples of p1 and p2 in different batches? dshah 2019-09-19 09:16
Ing. Helmut Schütz