Bioequivalence and Bioavailability Forum • Leads to a (pseudo-) period effect ?

Leads to a (pseudo-) period effect ? [Bioanalytics]

posted by Helmut – Vienna, Austria, 2019-09-19 17:59 (1673 d 10:51 ago) – Posting: # 20621
Views: 5,906

Dear Ohlbe,

❝ Would they really ? I would say yes if he had systematically a negative bias for period 1 and a positive bias for period 2, or vice-versa. As there will not be a single run for Period 1 samples and a single run for period 2 samples, that will not necessarily be the case: some subjects will get artificially a positive bias in P1, others in P2.

Now you confused me (even reading Ravuri’s OP again did not help). If periods are analyzed in single, separate batches it should not matter in a crossover due to the randomization. Prerequisite: Always keep the order of the batches for all subjects p1 → p2 → …

What would not work:

A paired design.
Periods split into different batches.

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Complete thread:

Crossover: samples of p1 and p2 in different batches? Ravuri sindhura 2019-09-18 19:16 [Bioanalytics]
- Crossover: samples of p1 and p2 in different batches? dshah 2019-09-19 09:16
  - Leads to a (pseudo-) period effect Helmut 2019-09-19 15:33
    - Leads to a (pseudo-) period effect ? Ohlbe 2019-09-19 15:50
      - Leads to a (pseudo-) period effect ?Helmut 2019-09-19 15:59
        
        Leads to a (pseudo-) period effect ? nobody 2019-09-19 16:21
        
        Almost entirely OT Helmut 2019-09-19 17:22
        
        Almost entirely OT nobody 2019-09-19 17:46
        
        Completely OT Helmut 2019-09-19 18:08
        
        Leads to a (pseudo-) period effect ? dshah 2019-09-20 07:52
        
        Leads to a (pseudo-) period effect ? nobody 2019-09-20 08:00
        Run ≠ batch? Helmut 2019-09-20 09:42
        
        Run ≠ batch Ohlbe 2019-09-20 10:37
        Run ≠ batch? dshah 2019-09-23 07:43
        
        Run ≠ batch? nobody 2019-09-23 08:36
    - Leads to a (pseudo-) period effect Ravuri sindhura 2019-09-23 13:04