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RegisterShould we also consider to validate the validation? [Dissolution / BCS / IVIVC]
posted by yjlee168 
– Kaohsiung, Taiwan, 2019-09-12 11:46 (1677 d 18:45 ago) – Posting: # 20591
Views: 6,137
Hi amer,
Right. It's really a great idea. Software validation is indeed a must and a good thing absolutely. However, I was wondering: should you validate RIVIVC package first? Supposed RIVIVC passes the validation, then should we use RIVIVC to validate Wagner-Nelson (implemented in ivivc for R)? To me, it sounds like using an apple to validate an orange. This report may provide a good start or some ideas. Finally, since the software validation (either the black box or the white box) largely replies on computer and human calculation processes, should we also consider how to validate software validation procedures too in the future?
It has been in my to-do list for a long time. I apologize about the delay. Anyway, this is a great idea too.
❝ I may be able to validate wagner-nelson in ivivc for R (assumes 1-comp model) with numerical deconvolution/convolution using RIVIVC package...
Right. It's really a great idea. Software validation is indeed a must and a good thing absolutely. However, I was wondering: should you validate RIVIVC package first? Supposed RIVIVC passes the validation, then should we use RIVIVC to validate Wagner-Nelson (implemented in ivivc for R)? To me, it sounds like using an apple to validate an orange. This report may provide a good start or some ideas. Finally, since the software validation (either the black box or the white box) largely replies on computer and human calculation processes, should we also consider how to validate software validation procedures too in the future?
❝ suggestion: the ivivc for R can be updated to do numerical deconvolution/convolution option because what if the disposition is not 1 comp, then wanger-nelson is limited.
It has been in my to-do list for a long time. I apologize about the delay. Anyway, this is a great idea too.
—
All the best,
-- Yung-jin Lee
bear v2.9.1:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here
All the best,
-- Yung-jin Lee
bear v2.9.1:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here
Complete thread:
- predicting in vivo PK profiles from in vitro data after establishing IVIVC amer 2019-09-09 05:04 [Dissolution / BCS / IVIVC]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- external predictability for ivivc yjlee168 2019-09-09 10:46
- external predictability for ivivc amer 2019-09-10 02:31
- identical pH Helmut 2019-09-10 10:58
- identical pH yjlee168 2019-09-10 15:30
- R scripts/codes for in-vivo conc. yjlee168 2019-09-10 15:13
- Software validation, another round Helmut 2019-09-10 15:37
- Deconvolution mittyri 2019-09-10 15:54
- Software validation, another round yjlee168 2019-09-11 10:29
- Software validation, another round Helmut 2019-09-11 13:39
- Software validation, another round amer 2019-09-12 05:26
- Should we also consider to validate the validation?yjlee168 2019-09-12 09:46
- Who inspects the inspectors? Helmut 2019-09-13 12:07
- Who inspects the inspectors? nobody 2019-09-13 12:55
- Sapienti sat Helmut 2019-09-13 12:59
- Who inspects the inspectors? nobody 2019-09-13 12:55
- Who inspects the inspectors? Helmut 2019-09-13 12:07
- Should we also consider to validate the validation?yjlee168 2019-09-12 09:46
- Software validation, another round amer 2019-09-12 05:26
- Software validation, another round Helmut 2019-09-11 13:39
- R scripts/codes for in-vivo conc. amer 2019-09-11 05:35
- Bioavailabity term in predicted in-vivo conc. yjlee168 2019-09-11 10:16
- Software validation, another round Helmut 2019-09-10 15:37
- identical pH Helmut 2019-09-10 10:58
- external predictability for ivivc amer 2019-09-10 02:31
- external predictability for ivivc yjlee168 2019-09-09 10:46
Ing. Helmut Schütz