predicting in vivo PK profiles from in vitro data after establishing IVIVC [Dissolution / BCS / IVIVC]

posted by amer – Australia, 2019-09-09 05:04 (336 d 02:08 ago) – Posting: # 20555
Views: 3,675

I have conducted IVIVC analysis using the IVIVC for R package, all good!

Now that I have estabished IVIVC levy plots (and regression equation); how can i predict the plasma concentrations profile if i have got a new in vitro dissolution profile (not used to establish ivivc) for the same formulation done in a different dissolution media? (i.e going backwards)

For the new dissolution data (not used to establish ivivc), i can calulate the predicted fraction absorbed using the regression equation from the constructed IVIVC. But then, how can i predict the in vivo plasma Pk profile from the predicted fraction absorbed? does the ivivc for R package do that? how? what is the r-script that i can use.

I am using R studio.

Thanks,

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