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Registertransit compartments... [PK / PD]
Hi Helmut,
» An idea: Parameterize models with rate-constants (instead of CL) and compare kel of the IR formulation with ka of the MR formulation. Are they similar?
as always - thanks for support and suggestion!
You know MR is a nightmare for ka modelling (that's why we go into one stage IVIVC sometimes).
For that particular case absorption was modelled with a transit compartments chain. So there's no simple Ka to compare...
» An idea: Parameterize models with rate-constants (instead of CL) and compare kel of the IR formulation with ka of the MR formulation. Are they similar?
as always - thanks for support and suggestion!
You know MR is a nightmare for ka modelling (that's why we go into one stage IVIVC sometimes).
For that particular case absorption was modelled with a transit compartments chain. So there's no simple Ka to compare...
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Kind regards,
Mittyri
Kind regards,
Mittyri
Complete thread:
- PK model parameters IR vs MR mittyri 2019-09-02 22:15
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- PK model parameters IR vs MR jag009 2019-09-03 16:07
- PK model parameters IR vs MR mittyri 2019-09-03 16:54
- PK model parameters IR vs MR ElMaestro 2019-09-03 17:43
- PK model parameters IR vs MR mittyri 2019-09-03 18:05
- Parameter-identifiability? Helmut 2019-09-07 13:03
- transit compartments...mittyri 2019-09-07 22:25
- No organs in (Pop)PK Helmut 2019-09-08 10:56
- transit compartments...mittyri 2019-09-07 22:25
- PK model parameters IR vs MR jag009 2019-09-03 16:07
Ing. Helmut Schütz